TRPC7

TRPC7 is a receptor-operated, DAG-activated, non-selective cation channel in the TRPC3/6/7 subgroup^[1]^[2]. Mechanistically, TRPC7 responds to PLC-linked receptor signaling and supports Ca²⁺ entry, with regulation by extracellular Ca²⁺ and protein kinase C distinguishing it from related isoforms^[1]^[3]. In disease models, TRPC7 contributes to pilocarpine-induced seizure initiation and CA3 epileptiform burst firing^[4]. TRPC7 also mediates UVB-associated tumorigenesis and supports lung adenocarcinoma cell growth and migration through intracellular Ca²⁺ mobilization^[5]^[6]. For experimental applications, pyrazolopyrimidine agonists activate TRPC3/6/7 and provide tools for functional analysis, although subtype selectivity remains limited^[7]. - TRPC7 links PLC-DAG signaling to Ca²⁺ entry in receptor-operated channel models. - TRPC7 differs from TRPC3/6 through constitutive activity and Ca²⁺/PKC regulation. - TRPC7 studies support seizure, UVB-tumorigenesis, and lung adenocarcinoma research models.

References:

[1]. Zhang X, et al. Transient receptor potential canonical 7: a diacylglycerol-activated non-selective cation channel. Handb Exp Pharmacol. 2014;222:189-204. [Content Brief]

[2]. Beck B, et al. TRPC7 is a receptor-operated DAG-activated channel in human keratinocytes. J Invest Dermatol. 2006 Sep;126(9):1982-93. [Content Brief]

[3]. Shi J, et al. Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol. 2004 Dec 1;561(Pt 2):415-32. [Content Brief]

[4]. Phelan KD, et al. Critical role of canonical transient receptor potential channel 7 in initiation of seizures. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11533-8. [Content Brief]

[5]. Hsu WL, et al. Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B. Aging Cell. 2020 Jan;19(1):e13075. [Content Brief]

[6]. Liang JL, et al. TRPC7 facilitates cell growth and migration by regulating intracellular Ca²⁺ mobilization in lung adenocarcinoma cells. Oncol Lett. 2023 Jan 24;25(3):92. [Content Brief]

[7]. Qu C, et al. Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem. 2017 Jun 8;60(11):4680-4692. [Content Brief]

TRPC7 Related Products (2):

By Type:	Pan (1)
By Effects:	Antagonist (1) Activator (1)

Cat. No.	Product Name	Effect	Purity

HY-161766

L687	Activator	99.49%
L687 is a potent activator of TRPC3/C6/C7 that can induce cellular uptake of oligonucleotides.

HY-162090

TRPC antagonist 1	Antagonist
TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC₅₀s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines.

Name
Email *

	Sorry, but the email address you supplied was invalid.