TRPC7

TRPC7 is a receptor-operated, DAG-activated, non-selective cation channel in the TRPC3/6/7 subgroup^[1][2]. Mechanistically, TRPC7 responds to PLC-linked receptor signaling and supports Ca²⁺ entry, with regulation by extracellular Ca²⁺ and protein kinase C distinguishing it from related isoforms^[1][3]. In disease models, TRPC7 contributes to pilocarpine-induced seizure initiation and CA3 epileptiform burst firing^[4]. TRPC7 also mediates UVB-associated tumorigenesis and supports lung adenocarcinoma cell growth and migration through intracellular Ca²⁺ mobilization^[5][6]. For experimental applications, pyrazolopyrimidine agonists activate TRPC3/6/7 and provide tools for functional analysis, although subtype selectivity remains limited^[7]. - TRPC7 links PLC-DAG signaling to Ca²⁺ entry in receptor-operated channel models. - TRPC7 differs from TRPC3/6 through constitutive activity and Ca²⁺/PKC regulation. - TRPC7 studies support seizure, UVB-tumorigenesis, and lung adenocarcinoma research models.